Bone and Joint Multi encapsulated in vegetarian capsules, is designed to deliver high quality ingredients, combining a marine coral calcium based balanced mineral supplement with potent bone and joint-targeted nutrients and botanicals. This premier bone and joint health formula is blended with SMP-44 high-grade marine coral powder from Okinawa, Japan, along with calcium and magnesium citrates, bioavailable amino acid chelated forms of seven other essential minerals, nutrients and herbs to enhance the absorption and utilization of calcium and other minerals (21 nutrients in total shown to enhance the absorption and utilization of calcium1), and additional vitamins and nutrients to make it a full multi-vitamin formula. Bone and Joint Multi and all ANI formulas are manufactured by a FDA registered, cGMP compliant laboratory.Millions of Americans suffer from degenerative arthritis, also known as osteoarthritis and osteoporosis, that to varying degrees is part of the natural aging process. This process can be controlled and not all individuals suffer from the same level of progression of this deterioration of bone and joint tissues. The "aging battle" that occurs within bone and joints can be summarized as demineralized and weakening of the bone and loss of cartilage and inflammation of the joint.In the case of osteoporosis, it is essential to maintain proper nutrient intake and essential cofactors for bone health and development. Simply put, on a daily basis the osteoblasts and osteoclasts within your body are battling to determine whether you will end the day with a net positive or net negative bone mineralization. Without proper nourishment and intervention the consequence is the end result of a net negative loss of bone mineralization and hence bone density.The joints within the body are maintained and repaired by chondrocytes, (the cartilage producing cells) within the joint that can become damaged or undernourished, compromising their ability to repair the joints. Secondly, inflammation, the literal medical translation being "-itis" hence the term osteoarthritis (bone-joint) leads to further destruction when not kept in check. The goal is simple: to provide the nutrients the body needs to repair the joints and maintain joint health.Bone and Joint Multi Formulation and Co-Nutrient Highlights Key to any bone and joint formula should be providing the general support to the body's entire musculo-skeletal system while focusing on the specific needs for optimal bone and joint health. Simply put, your bones and joints provide the structural integrity key to your entire musculo-skeletal health. All of these parts contribute to overall strength, resilience and quality of life.Mirroring Nature's highly ordered and well-delineated hierarchy of blending naturally occurring molecular substances and nutrients establishes the foundation for "Enhanced Support." This is nicely illustrated by the fact that one will never find pure, white crystalline ascorbic acid. Rather it is found in balance with naturally occurring bioflavonoids in fresh fruits and vegetables. Researchers have shown at least a 25% increased effectiveness of this synergistic blend of vitamin C and bioflavonoids than vitamin C by itself. The significance lying in the fact that sufficient vitamin C is essential for the cross-link of collagen to instill the inherent strength of this connective tissue fabric.In short, in nature's pharmacy there is truly no such thing as isolated "pharmaceutical grade" chemicals. Unlike a prescription drug, naturally occurring substances exist in balance. Thus, during the formulation process this inherent patterning was paralleled. A specialized technique called "stacking" was used to augment various nutrients with co-factors essential for proper metabolic effect and enhanced bio-effectiveness. Additionally, it is well documented that the production and maintenance of healthy bone and joint cartilage health is dependent upon sufficient quantities of numerous building blocks including calcium, magnesium, sulfur, glucosamine, hyaluronic acid, silica and numerous minerals. Therefore Bone and Joint Multi formula contains each of these vital factors as well as anti-inflammatory herbal ingredients:Calcium: Essential for bone strength and integrity. Magnesium: Counterpart to calcium, essential for healthy joints, muscles and cellular energy production. Boron: Assists with calcium metabolism and hormonal balance. Ipriflavone/Isoflavone: Augements calcium utilization and cellular metabolism. Isoflavones are phytoestrogens and may mitigate symptoms of menopause. Glucosamine: builds joint cartilage, reduces destruction of cartilage from NSAIDs, lubricates the joints, helps in formation of bones and ligaments 6. MSM: provides sulfur for glucosamine and collagen production and increases cell permeability to get nutrients in and waste products out Hyaluronic Acid: high concentration in joint fluid (lubricant) Bioflavonoids: helps repair broken capillaries plus antioxidant support and co-nutrient. Boswellia Serrata: support against pro-inflammatory enzymes. Vitamin D: Vitally important for calcium absorption from the intestine and for bone health. Yucca: supports chondroitin synthesis by suppressing endotoxins. Turmeric and Devil's Claw: provide additional joint support Red Algae Powder: Rich source of silica, important for connective tissue integrity. Everyone experiences the affects of aging that includes weakening of the bones and wear and tear of their joints in the course of normal daily activities. Those individuals that actively nourish their bodies to ward off the ravages of aging are far better equipped to support healthy bones and repair and maintain their joints maintain quality of life. The clinical indications are two-fold, either preventatively to help control permanent destruction and loss or as a healing agent with the intended goal of augmenting the body's naturally restorative mechanisms.Each serving of Bone and Joint Multi contains 1200 mg of natural marine coral from Okinawa, Japan. Suggested Use: Take 6 Bone and Joint Multi capsules daily with meals or as directed by a physician or health care practitioner. Since stomach acid is required to dissolve calcium, for best results take CORALadvantage with multiple meals throughout the day rather than in one large dose. Avoid taking with soft drinks that contain phosphoric acid since it binds with calcium and makes it un-absorbable. It is also better to not take with spinach and beet greens because Oxalic acid inhibits calcium absorption. Also avoid taking with iron supplements and sulfate containing supplements (e.g., chondroitin sulfate, glucosamine sulfate) due to the calcium-sulfate interaction. Note that acid forming foods including alcohol, caffeine, carbonated soft drinks, red meat, and saturated fats may increase the body's requirements for calcium and mitigate the benefits of increased calcium and mineral intake. Consult a health professional for more information.Bone and Joint Multi in Vegetarian Capsules contains no animal source ingredients.Cautions: This formula was designed to be well tolerated with support of the GI health being an important consideration. The ingredients in this formulation are generally well tolerated.